Showing posts with label PLOS One. Show all posts
Showing posts with label PLOS One. Show all posts

Monday, May 26, 2014

KENYA: CIRCUMCISING IS NOT PROTECTING AGAINST HIV

The real news: CIRCUMCISING IS NOT PROTECTING AGAINST HIV

Standard Digital (Kenya)
May 22, 2014

Male cut staff overwhelmed by work

by Gatonye Gathura
Kenya: The national male circumcision programme is in problems with most workers claiming burnout from high workload and impossible targets.

A survey of the programmes in Kenya, South Africa, Tanzania, and Zimbabwe shows local workers are the most fatigued.

Information coming directly from the workers indicates more than two thirds is already stressed while colleagues say this could be as high as 90 per cent.

“This is a worrying trend but not totally unexpected considering the repetitive nature of such procedures,” Dr George Githuka, the head of the programme, told The Standard yesterday.

He said with the new evidence, they will now seek a way out to save the workers from burnout while retaining them in the programme.

The survey carried out by among others Dr Peter Cherutich, deputy director at the National Aids and STI Control Programme, and edited by Nathan Ford of the World Health Organisation says worker fatigue could threaten what has become an example of success in Africa.

About seven years ago, Kenya set a target to increase the percentage of circumcised men nationally from 85 per cent to 94 per cent in three to five years by performing 860,000 procedures by last year.
But this work, which has won Kenya international accolades, is now said to have left workers totally exhausted.

The survey published two weeks ago in the journal Plos One had sampled 235 sites locally and some more in the other countries, with Kenya, which was the first to start the programme, having more workers say they are tired.

“The workers are burning out from performing a single task repeatedly in a high volume work environment that produces long work hours of intense effort,” says the study, which was funded by the American Government.

The physical strain of standing for many hours, and the monotony of repeating the same procedure are claimed to be some of the factors contributing to the fatigue.

EXTENDED PERIODS
“Other factors include attending to high volumes of clients over extended periods which translates into emotional exhaustion.”

These, the researchers say could be attributing to possible high rates of worker attrition from the programme. When asked about the impact of the scale-up of their work, the staff, both male and female, said the targets were not realistic which was leading to increased workload and hence the burnout.

“I don’t think the targets are the problem but it is mostly the repetitive nature of the job which can become monotonous,” says Dr Githuka.

Most studies on male circumcision, including the Kenya Aids Indicator Survey 2013 (KAIS), have so far concentrated on the quantity of procedures but none has shown it is achieving its primary objective of reducing HIV infections.

Started almost seven years ago, on the promise that it could reduce the risk of infection by 60 per cent, the KAIS report showed a spike in prevalence in places like Nyanza where the circumcision programme is most intense.

Circumcision status, condom use, and sexual behaviour were measured through participants’ self-report, and therefore, responses may have been biased toward socially desirable answers,” says the KAIS report, which was commissioned by the Ministry of Health.

But if Kenya is to meet her ambitious targets, the authors say it will need to retain experienced workers who are willing to complete large numbers of procedures in high volume settings.

“The country may have to consider how best to continue to motivate these workers to maintain job-fulfillment, reduce burnout, prevent attrition and maximise performance.”

Tuesday, February 19, 2013

NOTTINGHAM: African HIV trials fudged registration dates

So what else did they play fast and loose with?

Ripe Tomatoes, September 13, 2013


Circumcision and HIV

Two out of three key trials registered late

Does circumcision of adult men reduce HIV transmission? Initial scepticism, surely the foreskin reduces friction between penis and vagina, and prevents abrasions and blood transfer, and conflicting observational data, were eventually overcome by three randomised trials, one each from South Africa (click here), Kenya (click here) and Uganda (click here). In each trial men were randomly allocated to immediate circumcision or to wait for two years. All three trials showed about half the number of new HIV infections in the immediate circumcision group. The relevant Cochrane review (click here) summarises them as follows:

“The resultant incidence risk ratio (IRR) was 0.50 at 12 months with a 95% confidence interval (CI) of 0.34 to 0.72; and 0.46 at 21 or 24 months (95% CI: 0.34 to 0.62). These IRRs can be interpreted as a relative risk reduction of acquiring HIV of 50% at 12 months and 54% at 21 or 24 months following circumcision.”

The Cochrane reviewers judged “the potential for significant biases affecting the trial results [as] low to moderate”. Referring to selective reporting they wrote “All three trials clearly stated in their protocols that the primary outcome was HIV incidence. The risk of bias due to incomplete outcome reporting is therefore low in all three trials.”

The trial protocols have not been published so we have to trust that the Cochrane reviewers interpreted them correctly. But if they relied on trial registration documents (click here, for South Africa, here for Kenya and here for Uganda) they would have been misled. They they all indicate more of less the same primary outcomes and planned sample sizes as in the respective papers. But according to the date of first entry, only the Kenyan trial was prospectively registered. The South African trial was registered a year and a half after recruitment ended and seven days before the results were published! The Ugandan one a month after recruitment ended,and a month before publication.

Recruitment period Date of 1st publication of results 1st trial registration date Registry planned sample size Primary outcome in registry Primary outcome in paper
South Africa July 2002 – Feb 2004 26 July 2005 July 19 2005 3274 planned.
3274 in paper
HIV infection at 3, 12 and 21 months All HIV infections at 3, 12 and 21 months
Kenya Feb 2002 – Dec 12 2006 24 Feb 2007 April 23 2003 Initially 3,000. Altered to 2887 in registry.
2784 in paper
HIV incidence at 2 years
Complications of circumcision
HIV incidence after three interim analyses
Uganda August 2002 – Dec 2006 24 Feb 2007 Jan 23 2007 5,000 planned
4996 in paper.
HIV acquisition no time point specified HIV incidence

It looks like PLOS One and The Lancet wanted to publish sexy high impact trials, found they weren’t registered, so got the authors to do it retrospectively, and hoped no-one would notice! All three trials were funded by the public sector.

Jim Thornton (Professor of Obstetrics and Gynaecology at Nottingham University)