MedPage TodayJuly 26, 2014
Circumcising Men Cuts HIV Risk Among Women
by Michael Smith
Note that this study was published as an
abstract and presented at a conference. These data and conclusions
should be considered to be preliminary until published in a
peer-reviewed journal.
[That hasn't stopped the media from splashing it everywhere - as here - as headline news.]
MELBOURNE, Australia -- The HIV-preventing benefits of circumcision were not just restricted to men, researchers said.
In a region of South Africa where HIV prevalence is high, women whose
only sexual partners were circumcised had a significantly lower
prevalence of HIV, according to Kevin Jean, PhD, of the French National
Institute for Health and Medical research in Villejuif, France, and
colleagues.
Moreover, a mathematical model suggested that the incidence of HIV
among those women was also lower than among women whose partners
included uncircumcised men, Jean reported at the International AIDS
Conference here.
The finding -- the first evidence that women also benefit -- is a
"compelling argument" to speed up the roll-out of voluntary male
circumcision in Africa, Jean argued.
[No mention of the Wawer study in Uganda, which suggested that circumcising men INcreases the risk to women.]
Three randomized trials have shown that men who are circumcised are
at lower risk of acquiring HIV, including one in the Orange Farm
township of South Africa.
Researchers have since demonstrated that a free program of voluntary
circumcision could be widely accepted among men in the region, leading
to lower HIV prevalence among circumcised men.
But the missing piece of the puzzle has been what happens to women
when men are circumcised and the prevalence of HIV drops, as has
happened in Orange Farm, a township of about 110,000 adults near
Johannesburg.
[So this sample was also taken in Orange
Farm. How many of the same men were used? Over-testing the same sample
leads to less reliable data. The fact that ALL the studies claiming
benefits emerge from the same three sites, and the same cluster of
researchers, is increasingly suspicious.]
To find out, Jean and colleagues surveyed a total of 4,538 sexually
active women, ages 15-49, in three waves, in 2007, 2010, and 2012.
Participants were asked about their age, ethnic group, occupation,
age at first sexual intercourse, alcohol consumption, education, number
of lifetime partners, and consistent condom use.
They also were asked about the circumcision status of their partners,
and the researchers took a blood sample to analyze HIV prevalence in
the cohort, Jean said.
Among the 1,363 women who reported only having had circumcised
partners, the HIV prevalence was 22.4%, compared with 36.6% among the
remaining 3,175.
[This is quite a loose association - women's
HIV status vs her reporting of remembering ever had an intact partner.
It can be confounded by faulty memory, lack of interest or
misidentification.]
Mathematical modeling from the observed age-specific prevalence rates
yielded estimated incidence, Jean said. Although the researchers have
also measured new HIV cases in the cohort, that data is still being
analyzed, he said.
The analysis showed that incidence among women who only had
circumcised partners was 0.032 cases per person-year, compared with
0.039 per person-year among the remaining women.
[So circumcision reduces the risk by 0.006 cases per person-year? That's hardly impressive, even if true.]
The numbers yielded an incidence rate ratio of 0.83 and a risk
reduction of 16.9% for the women who only had circumcised partners, Jean
said. When the analysis was restricted to women 15 through 29, the risk
reduction was 20.3%, he added.
[Data-mining.]
The study extends previous research on circumcision in the region,
commented Stefano Vella, MD, of the Istituto Superiore di Sanita in
Rome, and a former president of the International AIDS Society.
Evidence is mounting that multiple prevention measures will be needed
to slow the HIV/AIDS pandemic, he said, and circumcision seems likely
to play an important role since it has been shown to offer partial
protection for men.
The evidence that the procedure also reduces the risk of HIV among women is of "paramount importance," he told reporters.
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